| ranoumeasewi | Date: Friday, 11.22.2013, 5:10 PM | Message # 1 |
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| The government on Thursday approved the 1st drug that promises to attack cancer by choking off its blood supply, a colon cancer treatment called Avastin.The drug merely has a modest benefit — it could extend the lives of patients with advanced cancer of the colon by about five months, the foodstuff and Drug Administration cautioned.But it's a significant development, because Avastin becomes the 1st drug proved to work based on a novel theory that tumors must form a network of veins to survive — and that shutting down that process, called angiogenesis, could fight cancer within a manner completely differently than anything else.That theory was pioneered by Harvard University's Dr. Judah Folkman, who made front-page news in 1998 with reports that his anti-angiogenesis drugs had cured mice of cancer. But attempt after make an effort to make such drugs are employed in people failed.Indeed, the software creator of Avastin, Genentech Inc., saw its stock plummet even as 2002 when the drug did not help breast cancer patients.Then doctors tried Avastin inside the sickest of colon cancer patients, those whose cancer has spread along with other parts of the body.In a study of 800 people, half received intravenous Avastin in addition to routine chemotherapy. Not only was tumor growth delayed in those getting Avastin, nevertheless the Avastin patients lived about 20 months, five months longer than those getting standard treatment.In patients that sick, even this kind of small benefit is considered medically important.What's more, it marked the first time in thirty years of research that an anti-angiogenesis drug was proven to help people.Avastin is a monoclonal antibody, a substance that seeks out and binds to one of the more 20 chemicals proven to help tumors' blood vessels grow. The one Avastin targets is called vascular endothelial growth factor, or VEGF. When Avastin binds with it, VEGF can't stimulate blood vessel growth, thus keeping tumors from growing by denying them nourishing blood.Avastin occasionally causes some serious unwanted side effects, the FDA cautioned. They include formation of holes inside the colon that may require surgery to repair, impaired wound healing and internal bleeding.More established side effects are high blood pressure, fatigue, thrombus, diarrhea, appetite loss and increased likelihood of infection because of decreased white blood cells. Many of the troops serving in Mosul originate from Virginia and from the condition of Washington. For their families, it has been excruciating to wait to find out if their loved ones are safe. An image in the Richmond Times-Dispatch of Sgt. Evan Byler, his blood-stained hand clutching a cigarette, brought fiancee Michele Gibson a unique gift this Christmas. "I was virtually hysterical all afternoon until I, no less than, saw the picture and saw that they was OK," she tells The first Show national correspondent Thalia Assuras. The happy couple became engaged this summer. Byler is part of the 276th Engineer Battalion, based at Richmond, Va.Byler survived the mess tent attack. However, there is the awful knowledge that others didn't. "I feel very bad for the families that lost whoever they lost," Gibson says, "but I am thankful that he's OK."Patricia Otto's husband, Lt. Shawn Otto, is additionally in the 276th. He called permit her know he is fine. Still, "knowing that other people were hurt, and some were lost, was only killing me inside. I'd a really rough day," she told Early Show co-anchor Rene Syer."Knowing he's safe makes me feel better, but I still feel within the sadness of the holidays (without him) and mourn for people who have lost people. And i also look forward to him coming home and realize that others will not be coming home, also it just kills me inside because I just love every single soldier there for what they're doing for us," Patricia Otto said from her Richmond, Va. home.Captain Chris Doss's Christmas stocking hangs in the mantle. He emailed his wife, Melissa, because attack was under way, with welcome news she hopes others receive, too. "There's other families that know that their soldier's OK. But there's a lot that don't. And I feel guilty which i know and that they don't," she says. The casualties originate from units across the country. In Fort Lewis, Wash., Leslie Swope waits for word of her husband. "It's very difficult, but they're over there for a reason. He wouldn't contain it any other way," she told Assuras.In Portland, Maine, Valerie Noble prays to be with her son. "I'm just hoping to God it's not him, but saying prayers for that families of the servicemen that are. What else can you do?"What's creating this a lot harder for the families is the military's communication blackout, Assuras notes. Until relatives in your house can reach their loved ones in Iraq, they could only hope those loved ones are probably the lucky ones.
Cholesterol (both bad and good) Blood pressure Blood sugar mulberry elgin William Cohen came close to giving Serb President Slobodan Milosevic an ultimatum Friday, reports CBS News National Security Correspondent David Martin .The U.S. Secretary of Defense warned that the crisis in Kosovo "has to be resolved certainly inside a week." That deadline is driven by the approach of winter and the danger it poses to the estimated 50,000 refugees that are living in the hills of Kosovo. They're afraid to return home because of the continuing presence of Serb army and police units inside the separatist province.However, while winter keeps closing in, the timetable for NATO military action keeps slipping. NATO is now not expected to authorize air strikes until Monday. U.S. officials believe that authorization of strikes can give special envoy Richard Holbrooke the clout he should convince Milosevic he has no choice but to accede to NATO demands.Holbrooke used to be engaged in protracted talks with Milosevic Friday night inside a last-ditch effort to stop the Kosovo crisis from changing into a shooting war.Holbrooke was attempting to persuade Milosevic to avert threatened NATO air strikes by obeying a six-point ultimatum from your Big Power Contact Group comprising the United States, its European allies and Russia.Holbooke did not have any comment about the talks, which State Department spoeksman James Foley referred to as "tough."Foley said the situation in Kosovo appeared to be quiet, but there was no sign more and more Yugoslav troops and police were meeting the U.N. demand which they end a bloody crackdown on pro-independence ethnic Albanians there.On Friday, what will be the last humanitarian aid to reach one of many worst-hit areas of Kosovo made its approach to a distribution point, reports CBS News Correspondent Allen Pizzey . American-donated food, wheat, blankets and foam mattresses reached ethnic Albanians that are desperately in need because their homes happen to be burned and bombed.Free access for relief agencies is probably the conditions the Serbs must meet in order to avoid air strikes.However, the relief effort for Kosovo has just about ground to a halt awaiting NATO bombing raids -- aid agencies have withdrawn many of their foreign staff out of concern for their own safety.Only a couple of Western aid workers are left in Kosovo, and people who have been forced to evacuate are bitter."The U.S. and NATO aren't telling us what's happening," said one, and worst of all there appears to be a total deficiency of concern about what happens in the ground after air strikes. Guerrillas of the Kosovo Liberation Army (KLA) fighting for independence were observing the first day of a unilateral cease-fire Friday. However, as you relief worker put it, unless some force will come in to take control on the ground in the event the bombing stops, the KLA and the Serbs will geback to business as always.From a humanitarian point of view, it does not take worst case scenario imaginable.©1998 CBS Worldwide Corp. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press and Reuters brought about this report
In this land of many opportunities, us just have ordinary jobs. For many people we don't dream, though, or try to weave in a little of the American dream into our 9-to-5 lives.Dan Rather tells how one West Virginian accomplishes that, as part of CBS News' continuing series around the American dream. Johnny Staats drives his brown truck with the hills of West Virginia. "I entered UPS in 1988 right after high school," he says. "Here in West Virginia, it really is hard to find a good job," Staats adds. For 11 years, he's delivered packages with plenty of cheer. "I enjoy my job," Staats reveals. Yet every chance he gets, wherever he is able to, Staats pulls out his mandolin and merely starts picking away. "I started after i was about 7 years old, and I have been playing ever since," he recalls. In ways Staats is a natural-born talent. "My mom plays the piano; and sister plays the banjo; and pa plays the guitar," he notes. "I employed to go up to my Uncle Glenn's house and pay attention to bluegrass all night," he notes on his Internet site.Bluegrass Heritage is the name with the band he joined at 9; he entered competitions at 13 or 14. In secondary school, "All the kids teased me about playing bluegrass since rock 'n' roll was real big then," he recalls. And it is often his life-long dream to play the mandolin professionally. (Younger crowd plays the guitar and the fiddle.)"All I believed about was playin' music, goin' to Nashville, cut a CD," he says. And he did. "Yeah, I just about fell in the chair; I couldn't trust it ya know," according to him.His music caught the ear of Nashville's Giant Records, plus it signed him to a big recording contract. "This will be the American dream for me; it don't get any better than this," he admits that, laughing. Staats says he'll go and record an audio track and pray for stardom, but he isn't hanging up his uniform to advance to Nashville - or at best not just yet. With a wife and 2 kids at home, he is acquainted with receiving a steady paycheck per week. So he is taking a "wait-and-see" approach to his American dream. "I probably will still be livin' in this farmhouse here; gone will be the mansion on the hill or Mercedes parked around back; it will still be the same old Johnny," he admits that.He'll try to live the very best of both worlds. His growing entourage includes the neighborhood pet shop owner who became his manager. "My advice to anybody is usually to keep plugging away and never give up because dreams are available true," Staats says. mulberry knightsbridge Tom Cruise and Nicole Kidman have won a reported six-figure sum in libel damages along with a retraction from a London newspaper that alleged their marriage is a sham and that Cruise is gay. CBS News Correspondent Kimberly Dozier reports from London."I really do not take a lot of pleasure in even having to be here today. This is the final recourse against anyone who has printed vicious lies about me and my children, and I intend to protect my family," said Cruise.Britain's Express on Sunday newspaper claimed in the article last year that theirs was a passionless marriage of convenience, applied for either as a business arrangement on the behest of the Church of Scientology or as a cover for the couple's mutual desire for the same sex.It also claimed that Cruise was impotent or sterile and they also adopted their two children impulsively. The newspaper's attorney apologized and said the allegations were entirely false.The couple's lawyer, libel specialist George Carman, said the American media should take note. "They admitted that all those actions are false now. It's enormously important since this should stop American publications from saying precisely the same kinds of things, because if they certainly it they will be doing it knowingly which will allow us to stop it," said Carman. Despite rumors that have dogged them, Cruise and Kidman married given that they love each other and their marriage is a close and happy one, their attorney said. Cruise said that's what the legal case was about. "It is certainly not about the money. Although we received an incredibly substantial sum, every single penny, pound we received should go to various charities,"says Cruise.For your media, both here and in the U.S., this is about the money. They will likely think twice about how much repeating this story is worth to them.Reported by CBS News Correspondent Kimberly Dozier
Pope John Paul II is get yourself ready for a historic visit to the Holy Land in the near future, part of his mission to heal longstanding wounds between Catholics and Jews. Speculate CBS News Correspondent Mark Phillips reports, some of the people wounds have just been re-opened.It could hardly happen to be a worse send-off from the Vatican around the eve of the pope's trip to Israel. The ghosts of Christian anti-Semitism, which the pope tried to bury, have been raised again by an essential papal advisor. Father Peter Gumpel, who investigates candidates for sainthood, has utilized language long-forbidden by the church to spell it out Jews.The Vatican official said, "Let us be frank and open concerning this as in all the things that I have said. The simple truth is that the Jews have killed Christ. It is really an undeniable historical fact."In fact, Vatican II removed references to the Jewish blame for Christ's crucifiction from church rites a lot more than 30 years ago on the grounds that such claims were historically debatable, hurtful and dangerous. And also the current pope has made repeated gestures of reconciliation toward Jews, you start with his visit to Rome's central synagogue in 1986.But Father Gumpelfrom their own Vatican pulpitexpresses a view which may be unfashionable but still exists there. "There is not any possibility to deny that the Jewish authorities, religious authorities of the time, said he has made himself God and according to our law he has to die," Gumpel has preached.From the influential upper reaches in the Vatican in this day and age, references to Jews as Christ killers are not only astonishing, they are decidedly unhelpful into a pope about to embark on an historic tour of Israel. Whatever gestures of reconciliation Pope John Paul himself may have made over the years, old attitudes here fervent. And these comments may have cast a pall over this whole trip.According to Gacobo Saban of the Union of Italian Jews, "Bother me, I'd say is not the correct term. Worry me, perhaps yes. I simply see these remarks being a sign that the past hasn't entirely disappeared."The pope's visit to Israel has been billed as a pilgrimage into Christianity's past. Despite his efforts, it is possible to some dark periods in this past that have not been fully confined to history. Children's advocates say her story belongs to a national epidemic of legal substance abuse in which children who are not mentally ill are prescribed powerful psychotropic medicines which may have only been safety tested for adults.
Michael Jackson allegedly staved off a young child molestation accusation in 1990 with a $2 million payment to the son of an employee at his Neverland Ranch, based on a television report.The television news magazine "Dateline NBC," which reports the payment inside a segment to be broadcast Friday, did not disclose its source of information.In the segment, retired Santa Barbara County Sheriff Jim Thomas says his office investigated Jackson in 1993 in connection with one boy's claim and uncovered the second accusation.The first boy reportedly was paid $15 million to $20 million by Jackson to prevent charges the entertainer thought would damage his career even if proved untrue.Jackson has denied ever harming any child and it is currently fighting charges he molested a boy in 2003.Jackson's lawyer, Thomas Mesereau Jr., didn't immediately return a call Thursday through the Associated Press. Lawyers in today's case are under a strict gag order."We always believed there have been eight to 10 other children around," Thomas told "Dateline."But during interviews, he stated, "Many of them said that they had frolicked with Michael Jackson. They had spent time in his bedroom, but that nothing had happened. Some wouldn't speak with us at all."Thomas told the AP the employee's son would not file charges and didn't want to testify "because he was afraid his friends would think he was homosexual."Thomas has mentioned the boy's claim, but said he wasn't sure prior to the Dateline report that Jackson had paid the boy $2 million."Dateline" said the settlement contained a clause barring it from being discussed publicly.Thomas said the 12-year-old accused Jackson of "fondling him through his clothes," that could be the basis of misdemeanor charges. No charges were ever filed.Both boys who accused Jackson inside the 1990s are now in their 20s and are not expected to testify in the current case.Jackson, 45, has pleaded innocent to committing a lewd solve a child, administering an intoxicating agent and conspiring to commit child abduction, false imprisonment and extortion. His trial is scheduled to start Jan. 31, 2005.By Linda Deutsch In the past year, two words emerged as a caption for America's resolve: President Bush's "Lets roll". From the ashes of Flight 93 came the storyline of Todd Beamer. Just before passengers started fighting back, he was on the telephone with operator Lisa Jefferson.Based on Jefferson, "He said, 'Okay, let's roll.'"But, as CBS News Correspondent John Blackstone reports, has America's embrace gone too far?Paul Pancucci runs one of lots of Internet businesses selling "Let's Roll" T-shirts.Pancucci says, "We wanted the letters to be bold and to make a statement."The U.S. Patent office has got at least 19 applications to make use of "Let's Roll" as part of a trademark.Among those claiming the phrase is the Todd Beamer Foundation that sells its own line of clothing and baseball caps to increase money for charity. Beamer's widow, Lisa, has just written a book titled "Let's Roll," an expression that's been an inspiration to many."There's and a piece of America that's merely a marketing machine, too, and wanting to profit off of things like this," Beamer told CNN's Larry King.When Florida State adopted "Let's Roll" because the motto of its football team, Coach Bobby Bowden found himself defending the option.Bowden explained, "Let's roll, let's download it today, you know, and so I thought it'd be a good tribute to those who died."The Beamer Foundation agreed it is a tribute, and is now receiving a share of the profits from "Let's Roll" gear purchased from Florida State colors.Still some on campus remain uneasy using the motto."It's not necessarily something that needs to be put on a T-shirt and shouted out," says one student."Let's Roll" has inspired songwriters, including Neil Young.However its political usage led Larry Lenza to produce a protest T-shirt.Lenza, of PoliticalClothing.com, says, "It was very unfortunate because individuals had gathered around the words first and then it was used in a cynical, political way." Anthony Pratkanis, a professor at U.C. Santa Cruz says, "In my head it's a phrase that's arrived at the ages. It's become part of just what it means to be American."Pratkanis, a specialist in consumer psychology, says "Let's Roll" is ready to accept abuse. "It plays on our emotions and gets us aroused and is used unfairly as a way of persuasion."Two words are now balanced somewhere between the trivial and the sacred.
The world's largest passenger plane, the Airbus A380, completed its maiden flight Wednesday, a milestone for aviation plus the European aircraft maker's fight with American rival Boeing Co.The giant plane landed successfully to applause at 2:22 p.m (8:22 a.m. EDT) from a flight of nearly four hours. About 30,000 spectators watched the behemoth take off and touch down, 101 years following the Wright brothers achieved the first controlled, sustained flight.The plane was carrying a crew of six and 22 tons of on-board test instruments."The takeoff went perfectly," Alain Garcia, an Airbus engineering executive, said on LCI television.The flight happened at the airport in Blagnac, a suburb of Toulouse in southwest France. It absolutely was beaming back real-time measurements to Airbus headquarters at Blagnac.There are cheers and applause as the white jet using a blue tail — its engines surprisingly quiet — grabbed speed down the runway and lifted smoothly into the blue skies. Fire trucks were stationed alongside the runway as a precaution.Airbus chief test pilot Jacques Rosay, flight captain Claude Lelaie and 4 crew members — who all wore orange flight suits — had to have no chances. Airbus had said they'd be wearing parachutes during the first flight, in accordance with company policy. A handrail leads from your cockpit to an escape door that can be jettisoned if the pilots lose control in the plane.The flight capped 11 numerous years of preparation and $13 billion in spending. Spectators camped by the airport to be there for some said was Europe's biggest aviation event because the first flight of the supersonic Concorde in 1969.The A380, which has a catalogue price of $282 million, represents an enormous bet by Airbus that international airlines will require bigger aircraft to transport passengers between ever-busier hub airports.The plane will carry around 800 passengers, with wider seats in coach class and unrivalled air luxury in high quality, reports CBS News Correspondent Elaine Cobbe. Facilities up to speed include a number of bars along with a library. Airlines can also choose fewer seats and more luxury, together with a casino and a gym. There are even plans for prison cells for rowdy passengers.However some analysts say signs of a boom in the market for smaller wide-body planes, such as Boeing's long-range 787 "Dreamliner," show Airbus was wrong to focus a lot time and money on its superjumbo. no previous page next 1/2 mulberry alexa bags Haley has already been testing drugs that could help. "We may be able to find a medicine that will regenerate those nerves and possibly relieve veterans of their symptoms," he was quoted saying.
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